It belongs to the group of androgens
Testosterone is essential for men for the development of reproductive organs. It belongs to the group of androgens. Male hormones are produced in the testes of men and to a small extent in adrenal glands. It has been reported that NR2E3/PNR regulates ESR1 (ERalpha) expression in ERalpha positive cell lines, and recent unpublished data from our group indicates it can heterodimerise with another nuclear receptor, PPARgamma. Therefore, this study investigates the hypothesis that BCL11A/NR2E3 complexes may contribute to repression of ESR1 expression in TNBC tumours. In addition, we wanted to investigate potential interactions of NR2E3/PNR and PPARgamma in breast cancer cells.
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